Cardiovascular disease (CVD) is a general term for heart and blood vessel disease, which includes coronary heart disease (disease of the blood vessels supplying the heart muscle), cerebrovascular disease (disease of the blood vessels supplying the brain), peripheral arterial vascular disease (disease of the blood vessels supplying the arms and legs), rheumatic heart disease (damage to the heart muscle and heart valves from rheumatic fever caused by streptococci), congenital heart disease (structural malformations of the heart present at birth), deep vein thrombosis and pulmonary embolism (blood clots in the veins of the legs, which can dislodge and move to the heart and lungs), etc.
Most CVDs are caused by behaviors such as smoking, unhealthy diet and obesity, lack of physical activity, and harmful use of alcohol. According to the World Health Organization (WHO), cardiovascular disease is the number one cause of death worldwide, and the number of deaths from it is increasing every year.
In addition to surgical procedures, there are various types and combinations of drugs used to treat cardiovascular disease, and Creative BioMart has been focusing on the use of recombinant therapeutic proteins in cardiovascular disease, including as targets for the development of therapeutic drugs for cardiovascular disease.
Therapeutic proteins in cardiovascular disease
Thrombopoietin (TPO) is a humoral growth factor that does not induce platelet aggregation per se, but triggers platelet activation in response to several agonists. Experimentally, researchers have demonstrated that TPO may enhance platelet activation in the early stages of unstable angina (UA) and may be involved in the pathogenesis of acute coronary syndromes.
This is an exciting study, and studies such as this one are not uncommon to report, so Creative BioMart offers researchers a recombinant human TPO to help you better investigate the relevance of TPO to acute coronary syndromes. Of course, this is just one aspect of our diverse therapeutic protein portfolio, and we have a large number of therapeutic proteins that can be used in cardiovascular disease research.
Because of the many years of research that have demonstrated the relevance of therapeutic proteins to cardiovascular disease, Creative BioMart is committed to providing researchers in this field with a diverse range of high-quality therapeutic protein products from a variety of sources and types. We believe that our therapeutic proteins can assist you in your research, whether it is in the development of drug targets or the investigation of pathogenesis. If you do not find the product you are looking for in this list, you can submit your request to our staff and we will be available 24/7 to answer your questions or assist you in purchasing the therapeutic protein product you are looking for.
Enrico, L., et al., (2006). “Thrombopoietin Contributes to Enhanced Platelet Activation in Patients With Unstable Angina.” Journal of the American College of Cardiology 48 (11) 2195-2203.