Alteplase; Human tissue plasminogen activator, tPA

Specification

• Cat#: THP-0010
• Product Name: Alteplase; Human tissue plasminogen activator, tPA
• Cas No: 105857-23-6
• Description: Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells.
• Sequences: SYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
• Species: Human
• Molecular Weight: 59042.3 Da
• Source: CHO
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C2569H3928N746O781S40
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Application: For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli.

Pharmaceutical Information

• Pharmaceutical Application: Alteplase
• Targets: Target 1. Plasminogen; Target 2. Fibrinogen alpha chain; Target 3. Urokinase plasminogen activator surface receptor; Target 4. Plasminogen activator inhibitor 1