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Conestat alfa; Recombinant C1 esterase inhibitor

Cat# : THP-0013

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0013 Conestat alfa; Recombinant C1 esterase inhibitor July 20, 2024 1 vial $3,998.00
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Cat#:  THP-0013
Product Name:  Conestat alfa; Recombinant C1 esterase inhibitor
Description:  C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and factor XIa. C1 esterase inhibitor has also been shown to inhibit the action of thrombin within the coagulation pathway, and tPA and plasmin within the fibrinolytic pathway. Deficiency of C1-inhibitor permits plasma kallikrein activation, which leads to the production of the vasoactive peptide bradykinin. Additionally, C4 and C2 cleavage goes unchecked, resulting in auto-activation of the complement system. Down-stream effects of the lack of enzyme inhibition by C1 esterase inhibitor results in swelling due to leakage of fluid from blood vessels into connective tissue and consequently the presentation of hereditary angioedema (HAE).
Sequences:  Not Available
Species:  Rabbit
Molecular Weight:  67000.0 Da
Purity:  >99% by SDS-Page and HPLC analysis
Cas No:  80295-38-1
Formula:  Not Available
Endotoxin Level:  <0.001 EU per 1 μg by the LAL method
Biological Activity:  2100 U/vial
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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  • Size: 100ug 500ug 1mg 5mg 10mg 100mg 500mg 1g
  • Conjugation: None R-PE APC Biotin FITC Alexa Flour Others

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