Cat# : THP-0020
Catalog# | Product Name | Availability | Size | Price | Qty |
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THP-0020 | Tenecteplase; Modified Tissue plasminogen activator (tPA) | October 08, 2024 | 100ug | $798.00 |
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500ug | $2,498.00 |
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1mg | $3,998.00 |
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Add to Cart Online Order Request a Bulk Order |
Cat#: | THP-0020 |
Product Name: | Tenecteplase; Modified Tissue plasminogen activator (tPA) |
Cas No: | 191588-94-0 |
Description: | Tissue plasminogen activator (tPA). The product is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. |
Sequences: | SYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGNWSTAESGAECTNWQSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAAAAASPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP |
Species: | Human |
Molecular Weight: | 58951.2 Da |
Purity: | >99% by SDS-Page and HPLC analysis |
Formula: | C2561H3919N747O781S40 |
Endotoxin: | <0.001 EU per 1 μg by the LAL method |
Biological Activity: | 8KU/vial |
Application: | For treatment of myocardial infarction and lysis of intracoronary emboli. |
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