Cat# : THP-0014
|Description:||The product is a direct inhibitor of human thrombin and has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. The product has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg by the LAL method|
|Applications:||Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.|
|Examples of Clinical Use:||Deep vein thrombosis undergoing hip replacement surgery|
|Pharmacodynamics:||The product results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).|
|Mechanism of action:||Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).|
|Affected organisms:||Not Available|
|Targets:||Target 1. Carboxypeptidase A1|
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