The product is a direct inhibitor of human thrombin and has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. The product has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.
>99% by SDS-Page and HPLC analysis
<0.001 EU per 1 μg by the LAL method
Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
Examples of Clinical Use:
Deep vein thrombosis undergoing hip replacement surgery
The product results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
Mechanism of action:
Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products
without prior written approval from Creative BioMart.
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