Desirudin

Specification

• Cat#: THP-0014
• Product Name: Desirudin
• Description: The product is a direct inhibitor of human thrombin and has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. The product has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.
• Sequences: Not Available
• Molecular Weight: 6963.52
• Purity: >99% by SDS-Page and HPLC analysis
• Cas No: 120993-53-5
• Formula: C287H440N80O110S6
• Endotoxin Level: <0.001 EU per 1 μg by the LAL method
• Biological Activity: 30mg/ml

Pharmaceutical Information

• Pharmaceutical Application: Desirudin
• Applications: Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
• Examples of Clinical Use: Deep vein thrombosis undergoing hip replacement surgery
• Pharmacodynamics: The product results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
• Mechanism of action: Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
• Affected organisms: Not Available
• Targets: Target 1. Carboxypeptidase A1