Desirudin

Specification Drug Information Related Products

Cat#:	THP-0014
Product Name:	Desirudin
Description:	The product is a direct inhibitor of human thrombin and has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. The product has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.
Sequences:	Not Available
Molecular Weight:	6963.52
Purity:	>99% by SDS-Page and HPLC analysis
Cas No:	120993-53-5
Formula:	C287H440N80O110S6
Endotoxin Level:	<0.001 EU per 1 μg by the LAL method
Biological Activity:	30mg/ml

Drug Name:	Desirudin
Applications:	Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
Examples of Clinical Use:	Deep vein thrombosis undergoing hip replacement surgery
Pharmacodynamics:	The product results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
Mechanism of action:	Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).
Affected organisms:	Not Available
Targets:	Target 1. Carboxypeptidase A1