GLP-1R/GCGR Dual Agonist (IBI362 (Mazdutide Biosimilar))

Specification

• Cat#: THP-467
• Product Name: GLP-1R/GCGR Dual Agonist (IBI362 (Mazdutide Biosimilar))
• Description: GLP-1R/GCGR Dual Agonist (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. It is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). IBI-362 binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). IBI-362 is used in studies of obesity and type 2 diabetes (T2D).
• Sequences: His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
• Molecular Weight: 4563.06
• Purity: 0.9994
• Formula: C210H322N46O67
• Storage: Sealed storage, away from moisture and light, under nitrogen. Powder: -80 centigrade 2 years; -20 centigrade 1 year.