Cat# : THP-0084
|Product Name:||Methoxy polyethylene glycol-epoetin beta|
|Description:||The product is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than EPO.|
|Molecular Weight:||Not Available|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg by the LAL method|
|Drug Name:||Methoxy polyethylene glycol-epoetin beta|
|Applications:||For the treatment of patients with anaemia associated with chronic kidney disease. Not a substitute for RBC transfusion if immediate correction of anemia is required.|
|Examples of Clinical Use:||Anaemia associated with chronic kidney disease|
|Pharmacodynamics:||Stimulates hemoglobin production by stimulating the erythropoetin receptor of erythroid progenitor cells in the bone marrow. Hemoglobin increase, following a single initial dose, occurs 7 to 15 days after.|
|Mechanism of action:||Erythropoietin is a growth factor for erythroid development. It is produced in the kidney and released into the bloodstream in response to hypoxia, interacting with erythroid progenitor cells to increase red blood cell production. Production of endogenous erythropoietin is impaired in patients with chronic kidney disease (CKD), and erythropoietin deficiency is the primary cause of their anaemia. Administration of methoxy polyethylene glycol-epoetin beta acts like endogenous erythropoetin and stimulates erythropoetin receptor of the erythroid progenitor cells in the bone marrow.|
|Affected organisms:||Not Available|
|Targets:||Target 1. Erythropoietin receptor|
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