Abaloparatide, Human PTHrP Peptide

Specification

• Cat#: THP-0148
• Product Name: Abaloparatide, Human PTHrP Peptide
• Cas No: 247062-33-5
• Description: The product is an analog of PTHrP (parathyroid hormone-related protein), a synthetic peptide that is related to hPTHrP and has demonstrated in testing the potential to widen the anabolic window for bone therapeutics, stimulating bone formation with a limited effect on bone resorption and mineral mobilization. This could enable improved convenience over currently available anabolic therapies, resulting in greater compliance and, ultimately, greater benefit.
• Sequences: AVSEHQLLHDKGKSIQDLRRRELLEKLLXKLHTA
• Species: Human
• Molecular Weight: 3961.0 Da
• Source: synthetic peptide
• Purity: >99.5% by SDS-Page and HPLC analysis
• Formula: C174H300N56O49
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Biological Activity: 2000 ug/1mL
• Storage: Lyophilized peptide should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted peptide solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Application: Investigated for use/treatment in postmenopausal osteoporosis to reduce vertebral and/or non-vertebral fractures.

Pharmaceutical Information

• Pharmaceutical Application: Abaloparatide
• Targets: Target 1. Parathyroid hormone/parathyroid hormone-related peptide receptor