Cat# : THP-0148
|THP-0148||Abaloparatide, Human PTHrP Peptide||April 02, 2023||1mg||$998||
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|Product Name:||Abaloparatide, Human PTHrP Peptide|
|Description:||The product is an analog of PTHrP (parathyroid hormone-related protein), a synthetic peptide that is related to hPTHrP and has demonstrated in testing the potential to widen the anabolic window for bone therapeutics, stimulating bone formation with a limited effect on bone resorption and mineral mobilization. This could enable improved convenience over currently available anabolic therapies, resulting in greater compliance and, ultimately, greater benefit.|
|Molecular Weight:||3961.0 Da|
|Purity:||>99.5% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg of the peptide by the LAL method|
|Biological Activity:||2000 ug/1mL|
|Storage:||Lyophilized peptide should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted peptide solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.|
|Applications:||Investigated for use/treatment in postmenopausal osteoporosis to reduce vertebral and/or non-vertebral fractures.|
|Examples of Clinical Use:||Postmenopausal osteoporosis|
|Pharmacodynamics:||The product, a proprietary analog of human parathyroid hormone-related protein (hPTHrP), is currently undergoing clinical trials by the company for the treatment of osteoporosis in postmenopausal women. PTHrP is a critical peptide for promoting new bone formation, with a distinct role from parathyroid hormone, or PTH, which primarily regulates calcium homeostasis and bone resorption. Clinical studies show increased bone mineral density (BMD) and levels of bone formation markers in a dose-response relationship.|
|Mechanism of action:||In target cells, abaloparatide acts as an agonist on PTH type 1 receptor (PTH1R) and activates both G protein–mediated cAMP signaling and β-arrestin-mediated ERK-1/2 signaling pathways with similar potency [A19105]. Abaloparatide binds to RG conformation of PTH1R with greater selectivity that results in more transient cell signalling responses.|
|Affected organisms:||Humans and other mammals|
|Targets:||Target 1. Parathyroid hormone/parathyroid hormone-related peptide receptor|
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