Human Secretin

Specification

• Cat#: THP-0043
• Product Name: Human Secretin
• Cas No: 108153-74-8
• Description: The product is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5. The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system. The product, also referred to as RG1068. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids. The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin.
• Sequences: HSDGTFTSELSRLREGARLQRLLQGLV
• Species: Human
• Molecular Weight: 3039.44 Da
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C130H220N44O39
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Biological Activity: 75 unit / vial
• Application: Indicated for the stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.gastrin secretion to aid in the diagnosis of gastrinoma. The product to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

Pharmaceutical Information

• Pharmaceutical Application: Secretin human
• Targets: Target 1. Secretin receptor