Cat# : THP-0133
|Product Name:||Liraglutide, GLP-1 peptide|
|Description:||This peptide is a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist. It is 97% homologous to native human GLP-1 by substituting arginine for lysine at position 341 and is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor.|
|Molecular Weight:||3751.2 Da|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg of the protein by the LAL method|
|Biological Activity:||6 mg/ml|
|Applications:||For use in/treatment of diabetes mellitus type 2.|
|Examples of Clinical Use:||Diabetes mellitus type 2|
|Pharmacodynamics:||The product is a once-daily GLP-1 derivative for the treatment of type 2 diabetes. GLP-1, in its natural form, is short-lived in the body (the half-life after subcutaneous injection is approximately one hour), so it is not very useful as a therapeutic agent. However, the product has a half-life after subcutaneous injection of 11–15 hours, making it suitable for once-daily dosing. The prolonged action of the product is achieved by attaching a fatty acid molecule at one position of the GLP-1 molecule, enabling it to bind to albumin within the subcutaneous tissue and bloodstream. The active GLP-1 is then released from albumin at a slow, consistent rate. Binding with albumin also results in slower degradation and reduced elimination of the product from the circulation by the kidneys compared to GLP-1.|
|Mechanism of action:||Liraglutide is an acylated GLP-1 (Glucagon-Like Peptide-1) receptor agonist. Liraglutide upregulates intracellular cAMP resulting in the release of insulin given elevated blood glucose concentrations. Glucagon secretion is also decreased in a glucose-dependent fashion by liraglutide.|
|Affected organisms:||Humans and other mammals|
|Targets:||Target 1. Glucagon-like peptide 1 receptor; Enzyme 1. Dipeptidyl peptidase 4; Enzyme 2. Neprilysin|
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