Recombinant RSV (subgroup B/strain 18537) Post-fusion F-trimer Protein

Specification

• Cat#: THP-0537
• Product Name: Recombinant RSV (subgroup B/strain 18537) Post-fusion F-trimer Protein
• Description: Recombinant RSV (strain 18537) Fusion glycoprotein F0 is produced by a Mammalian expression system. The target gene encoding Gln26-Leu513 is expressed with a C-terminal 6His tag. Mutations are introduced to stabilize the trimeric post-fusion conformation.
• Molecular Weight: 54.3 kDa
• Introduction: Respiratory syncytial virus (RSV) is a prevalent respiratory pathogen causing significant morbidity in vulnerable populations. The RSV Fusion (F) protein is a key vaccine antigen, targeted by neutralizing antibodies. It mediates membrane fusion by transitioning from a labile prefusion form to a stable postfusion form. The inactive F0 precursor is processed by furin proteases into F1, F2, and p27 subunits. While neutralizing epitopes exist on both forms, prefusion-specific epitopes are more potent. Understanding the structural transition of F protein is central to vaccine development efforts.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g