Recombinant RSV (subgroup A/strain Long) G Protein

Specification

• Cat#: THP-0536
• Product Name: Recombinant RSV (subgroup A/strain Long) G Protein
• Description: Recombinant RSV (subgroup A/strain Long) glycoprotein G is generated using a Mammalian expression system. The target gene encoding His67-Gln298 is expressed with a C-terminal 6His tag.
• Molecular Weight: 26.3 kDa
• Introduction: Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants and the elderly. The RSV G protein is a glycosylated membrane protein with an extracellular ectodomain containing a central conserved domain (CCD) characterized by four highly conserved cysteine residues. This CCD includes a CX3C chemokine motif (aa 182–186) that mediates viral attachment to CX3CR1-bearing cells. The G protein initiates infection by binding to cell surface heparan sulfate. Additionally, secreted G protein functions as an antigen decoy and modulates leukocyte activity via Fcgamma receptors, aiding immune evasion. Unlike other paramyxovirus attachment proteins, RSV G lacks hemagglutinating and neuraminidase activities.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g