Recombinant RSV Post-fusion F-trimer Protein (strain A2)

Specification

• Cat#: THP-0540
• Product Name: Recombinant RSV Post-fusion F-trimer Protein (strain A2)
• Description: Recombinant RSV (strain A2) Post-fusion F-trimer Protein is generated using a Mammalian expression system. The target gene encoding Gln26-Asn524 (with Phe137-Gly145 deletion) is expressed with a C-terminal 8His tag.
• Molecular Weight: 55.4 kDa
• Introduction: Respiratory syncytial virus (RSV) is a major respiratory pathogen. The Fusion (F) glycoprotein is the principal target for neutralizing antibodies. F protein mediates membrane fusion through a conformational change from prefusion to postfusion states. The F0 precursor is processed by furin-like proteases. While both conformations share epitopes, prefusion-specific antibodies are more potent. Structural characterization of these states guides rational vaccine design.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution containing 40mM Tris-HCl, 500mM NaCl, and 0.01% Tween 20, pH 7.4.
• Size: 50μg/500μg/1g