Recombinant MPXV M1R Protein

Specification

• Cat#: THP-0526
• Product Name: Recombinant MPXV M1R Protein
• Description: Recombinant MPXV M1R Protein is generated using a Mammalian expression system. The target gene encoding Gly2-Gly183 is expressed with a C-terminal 6His tag.
• Molecular Weight: 20.1 kDa
• Introduction: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), an orthopoxvirus. M1R is homologous to the vaccinia virus L1 protein, a highly conserved transmembrane protein on the intracellular mature virion (IMV) surface. Encoded by the L1R ORF, it is essential for virion assembly, entry, and maturation. L1 is required for low pH-induced cell-cell fusion and viral replication. It interacts physically with the entry/fusion complex (EFC), specifically A28, and indirectly with F9. While L1-MVs attach to cells, they require L1 for entry and fusion. As a myristoylated protein on the IMV surface, L1R is a potent target for neutralizing antibodies.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g