Recombinant MPXV E8L Protein

Specification

• Cat#: THP-0525
• Product Name: Recombinant MPXV E8L Protein
• Description: Recombinant MPXV E8L Protein is produced by a Mammalian expression system. The target gene encoding Met1-Thr275 is expressed with a C-terminal 6His tag.
• Molecular Weight: 32.7 kDa
• Introduction: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), an orthopoxvirus. The MPXV E8L protein is homologous to the vaccinia virus D8L protein, which binds cellular chondroitin sulfate (CS), facilitating a distinct virus-GAG interaction. As an abundant 32-kDa IMV protein, D8L is crucial for virus adsorption and entry. D8L elicits strong humoral and cellular immune responses; antibodies against it show neutralizing activity in vitro, while soluble D8L inhibits viral adsorption. DNA vaccines encoding D8L provide partial protection against lethal vaccinia challenge in mice and enhance the efficacy of polyvalent vaccines.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g