Recombinant MPXV B6R Protein

Specification

• Cat#: THP-0524
• Product Name: Recombinant MPXV B6R Protein
• Description: Recombinant MPXV B6R Protein is generated using a Mammalian expression system. The target gene encoding Thr20-His279 is expressed with a C-terminal 6His tag.
• Molecular Weight: 29.6 kDa
• Introduction: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), an orthopoxvirus. The B6R host-range protein is an outer envelope protein on extracellular enveloped virions (EEV). Homologous to vaccinia virus complement control protein B5, it negatively regulates complement activation. This 42-kDa glycoprotein contains four short consensus repeat (SCR) domains. B5 is a primary target for neutralizing antibodies and is vital for viral morphogenesis, trafficking, and EEV production. Conserved across orthopoxviruses, antibodies against B5 protect hosts from vaccinia challenge by neutralizing EEVs, though the mechanism remains defined.
• Purity: Purity exceeds 90% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g