Recombinant MPXV A29L Protein

Specification

• Cat#: THP-0520
• Product Name: Recombinant MPXV A29L Protein
• Description: Recombinant MPXV A29L Protein is produced by an E. coli expression system. The target gene encoding Ser21-Glu110 is expressed with a C-terminal 6His tag.
• Molecular Weight: 11.4 kDa
• Introduction: Monkeypox is a zoonotic disease caused by the monkeypox virus (MPXV), an orthopoxvirus. The A29L protein is an intracellular mature virion (IMV) surface envelope protein homologous to the vaccinia virus (VACV) A27 and is conserved across Poxviridae. The A27L protein (p14) is multifunctional, implicated in viral attachment, fusion, and plaque formation. A27 presence in IMVs inhibits fusion protein A26 assembly. Following endocytosis, acidic conditions trigger A26 dissociation, allowing viral-vesicle membrane fusion. A27 anchors A26 to the mature virus (MV) by interacting with the integral membrane protein A17 and forming a disulfide-linked complex with A26.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution containing PBS and 300mM NaCl, pH 7.4.
• Size: 50μg/500μg/1g