Recombinant MERS-CoV S-trimer Protein (R751S, C-6His)

Specification

• Cat#: THP-0519
• Product Name: Recombinant MERS-CoV S-trimer Protein (R751S, C-6His)
• Description: Recombinant MERS-CoV S-trimer Protein is generated using a Mammalian expression system. The target gene encoding Tyr18-Lys1294 with the R751S mutation is expressed with a C-terminal 6His tag.
• Molecular Weight: 145 kDa
• Introduction: The coronavirus spike (S) glycoprotein features protrusions that selectively bind host cell receptors. Known S1 receptors include ACE2, DPP4, APN, CEACAM1, sialic acid, and O-acetylated sialic acid. The S protein is crucial for viral attachment at the onset of infection. It is a large type I transmembrane protein comprising S1 and S2 subunits. S1 contains the receptor-binding domain (RBD) for cell recognition, while S2 contains elements required for membrane fusion. The S protein plays a key role in eliciting neutralizing antibodies, T-cell responses, and protective immunity.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g