Recombinant Human ACE-2 (C-6His)

Specification

• Cat#: THP-0505
• Product Name: Recombinant Human ACE-2 (C-6His)
• Description: Recombinant Human Angiotensin-Converting Enzyme 2 is produced by a Mammalian expression system. The region encoding Gln18-Ser740 is expressed with a C-terminal 6His tag.
• Molecular Weight: 84.63kDa
• Introduction: Angiotensin-Converting Enzyme 2 (ACE-2) is a zinc metalloprotease and integral membrane protein belonging to the ACE family, which comprises somatic and germinal types. As a carboxypeptidase, ACE-2 cleaves Angiotensin I to Angiotensin 1-9 and Angiotensin II to Angiotensin 1-7. It also efficiently hydrolyzes dynorphin-13 and apelin-13. ACE-2 is highly expressed in the heart, kidney, and testis, with moderate levels in the colon, ovary, and small intestine. Unlike classical ACEs, its activity is not inhibited by lisinopril or captopril. ACE-2 plays a potential role in cardiac function regulation.
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Stability: Product bioactivity remains stable after 14 repeated freeze-thaw cycles. Stability is verified by binding assays with SARS-CoV-2 S Protein RBD(C-mFc)(DRA32) after 14 days of storage at 4°C and 25°C, showing no significant variation.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g