Recombinant BRSV(strain BO/SWUN-2/21/CH) Prefusion F-trimer Protein

Specification

• Cat#: THP-0488
• Product Name: Recombinant BRSV(strain BO/SWUN-2/21/CH) Prefusion F-trimer Protein
• Description: Recombinant BRSV (strain BO/SWUN-2/21/CH) prefusion F-trimer is produced by a Mammalian expression system. The target gene encoding Gln21-Leu508 is expressed with a C-terminal 8His tag. Mutations are introduced to stabilize the trimeric prefusion state of the BRSV Fusion glycoprotein.
• Molecular Weight: 55.2 kDa
• Introduction: Bovine respiratory syncytial virus (BRSV), an enveloped, non-segmented, negative-stranded RNA virus of the order Mononegavirales, is a major cause of respiratory disease in cattle worldwide. The BRSV virion comprises a lipid envelope derived from the host plasma membrane containing three surface glycoproteins: the large glycoprotein G, the fusion protein F, and the small hydrophobic protein SH. The attachment (G) and fusion (F) proteins are the primary protective antigens. The F protein is a type I membrane-bound glycoprotein that mediates viral-host membrane fusion to initiate infection. Synthesized as a single F0 precursor polypeptide, it is post-translationally cleaved into two disulfide-linked subunits.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g