Proteins are an important part of normal body function and exist in many
different categories, and the body naturally makes many proteins that also
play different specific roles in the body. For certain diseases, the delivery
of a protein with a biological effect into the body may have a beneficial
effect on the patient, and this type of protein is known as a therapeutic
Most therapeutic proteins are derived from genetically modified animal
or microbial cells, and scientists can identify genes encoding specific
proteins in humans and then transfer the target genes into the animal or
microbial cells to obtain many therapeutic proteins of non-natural origin.
In contrast, natural products, which are metabolites synthesized by natural
organisms in the course of their life activities, are used to treat a wide
range of major diseases, such as cardiovascular diseases, malignancies,
immune diseases, and infectious diseases. Compared with chemically synthesized
therapeutic protein drugs, natural therapeutic protein drugs have obvious
advantages in terms of structural novelty, biocompatibility, and functional
diversity, and have been naturally selected and optimized during long-term
Figure 1. An overview of intricate association of natural compounds and
proteostasis machinery (Arun, U., 2021).
Human proteins exist in human sources or may exist in animals with similar
proteins. Of course, proteins obtained from plants and animals, and other
natural sources may also have different medicinal values because they can
regulate many cellular proteins and affect some relevant signaling pathways.
The main sources of these proteins with great medicinal value include bacterial
or fungal isolates, extracts from marine animals or plants, and a few specific
mammalian tissue secretions. Levels of therapeutic proteins from natural
sources are usually low, for example, the common insulin is a natural human
therapeutic protein that plays a critical role in regulating blood sugar.
Some therapeutic proteins of natural origin are blood factors that help
wounds clot to stop blood loss.
Some therapeutic proteins of natural origin work as part of the immune
system, helping to target and kill harmful invaders in the body.
Some therapeutic proteins of natural origin can signal and promote specific
types of growth.
All naturally sourced therapeutic proteins offered by
are formulated to be stable and retain their full activity, and there
are hundreds of natural therapeutic proteins for which product information
has not been updated and are not listed in the website's product catalog
at this time. Therefore, if you do not see the natural therapeutic protein
product you need on our website (including products from any source and
in any size package), please
us in the first instance. Of course, in addition to inquiries about available
products, you can submit information about any of your product needs with
our staff, and we will give you a satisfactory answer at the first opportunity.
Arun, U. (2021). 'Natural compounds in the regulation of proteostatic
pathways: An invincible artillery against stress, ageing, and diseases.'
Acta Pharmaceutica Sinica B
11 (10), 2995-3014.