Bacterial/Permeability-Increasing Protein (BPI)

Specification

• Cat#: THP-0245
• Product Name: Bacterial/Permeability-Increasing Protein (BPI)
• Description: The native protein BPI is isolated from human buffy coats and has a molecular mass of 53kDa. BPI encodes a lipopolysaccharide binding protein. BPI is related to human neutrophil granules and has bactericidal activity on gram-negative organisms.
• Molecular Weight: 53 kDa
• Source: Human
• Introduction: Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
• Purity: >70% as determined by SDS-PAGE and capillary electrophoresis.
• Application: BPI is toxic only toward Gram-negative bacteria. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.