Batroxobin

Specification

• Cat#: THP-0212
• Product Name: Batroxobin
• Cas No: 9039-61-6
• Description: Batroxobin is a defibrinogenating hemostatic agent derived from the venom of a pit viper, Bothrops atrox moojeni. In addition to batroxobin, the venom of Bothrops atrox has a composition of 10.2% neutral carbohydrate. Batroxobin is a serine protease, which cleaves the 16 Arginine - 17 Glycine bond in fibrinogen. The MW of batroxobin is approximately 43,000 g/mol-1, and it contains 231 amino acids.
• Sequences: Not Available
• Molecular Weight: Not Available
• Formula: Not Available
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Application: No approved indications. The product is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
• Publication: Contributions of thrombin targets to tissue factor‐dependent metastasis in hyperthrombotic mice (Yokota, N., Zarpellon, A., Chakrabarty, S.,et al.) (Journal of Thrombosis and Haemostasis) (2014).
  

Pharmaceutical Information

• Pharmaceutical Application: Batroxobin