Biotinylated 2019-nCoV S Protein RBD (N501Y, C-6His-Avi)

Specification

• Cat#: THP-0404
• Product Name: Biotinylated 2019-nCoV S Protein RBD (N501Y, C-6His-Avi)
• Description: Recombinant SARS-CoV-2 S-RBD is expressed in a Mammalian system. The target gene encoding Arg319-Phe541 with the N501Y mutation is fused with C-terminal 6His and Avi tags.
• Molecular Weight: 27.8kDa
• Introduction: The coronavirus spike (S) glycoprotein is critical for binding to host cells during the initial infection phase, notably in severe acute respiratory syndrome (SARS). The SARS-CoV S glycoprotein mediates membrane fusion necessary for viral entry and cell fusion, acting as a key immunogen and target for entry inhibitors. 2019-nCoV infects human respiratory epithelial cells by interacting with the ACE2 receptor. The S protein is a large type I transmembrane protein with S1 and S2 subunits. The S1 subunit contains the receptor-binding domain (RBD) responsible for recognizing cell surface receptors, while S2 contains essential fusion elements. The S protein is central to the induction of neutralizing antibodies, T-cell responses, and protective immunity.
• Purity: Purity exceeds 95% as assessed by reducing SDS-PAGE (QC verified).
• Storage: Upon reconstitution, store samples at -20°C or lower. The product remains stable for a minimum of 24 months under recommended storage conditions.
• Shipping Conditions: Transported using dry ice packs. Immediate storage at the specified temperature is required upon receipt.
• Formulation: Provided as a 0.2 μm filtered solution in PBS, pH 7.4.
• Size: 50μg/500μg/1g