Cat# : THP-0220
|THP-0220||Tumor Necrosis Factor alpha (TNF-alpha)||June 05, 2023||1 vial||$3,998.00||
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|Product Name:||Tumor Necrosis Factor alpha (TNF-alpha)|
|Description:||Recombinant TNF-alpha protein (Val 77-Leu 233) is expressed in E.coli, with an initial Met at the N-terminus.|
|Molecular Weight:||The recombinant human TNF-α consists of 158 amino acids and has a predicted molecular mass of 17.4 kDa which is also estimated by SDS-PAGE.|
|Introduction:||Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD12a; p55/6) and TNF-R2 (TNF receptor type 2; CD12b; p75/8), bind to TNF-alpha.|
|Purity:||>95 % as determined by SDS-PAGE|
|Formulation:||Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.|
|Endotoxin Level:||<5EU per 1 mg of the peptide by the LAL method|
|Biological Activity:||Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 5-50 pg/mL. Labeled biotin to TNF-alpha Protein, Human, Recombinant by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of TNF-alpha Protein, Human, Recombinant, Biotinylated bound to Humira was 0.1 nM.|
|Applications:||TNF-alpha is involved in fighting against the tumorigenesis.|
|Examples of Clinical Use:||Fighting against the tumorigenesis|
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