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Tumor Necrosis Factor alpha (TNF-alpha)

Cat# : THP-0220

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0220 Tumor Necrosis Factor alpha (TNF-alpha) March 01, 2024 1 vial $3,998.00
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Cat#:  THP-0220
Product Name:  Tumor Necrosis Factor alpha (TNF-alpha)
Description:  Recombinant TNF-alpha protein (Val 77-Leu 233) is expressed in E.coli, with an initial Met at the N-terminus.
Species:  Human
Molecular Weight:  The recombinant human TNF-α consists of 158 amino acids and has a predicted molecular mass of 17.4 kDa which is also estimated by SDS-PAGE.
Source:  E. coli
Introduction:  Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD12a; p55/6) and TNF-R2 (TNF receptor type 2; CD12b; p75/8), bind to TNF-alpha.
Purity:  >95 % as determined by SDS-PAGE
Formulation:  Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Endotoxin Level:  <5EU per 1 mg of the peptide by the LAL method
Biological Activity:  Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 5-50 pg/mL. Labeled biotin to TNF-alpha Protein, Human, Recombinant by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of TNF-alpha Protein, Human, Recombinant, Biotinylated bound to Humira was 0.1 nM.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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