Thrombomodulin Alfa

Specification

• Cat#: THP-0097
• Product Name: Thrombomodulin Alfa
• Description: The product is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Purity: >99% by SDS-Page and HPLC analysis
• Cas No: 120313-91-9
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: Thrombomodulin Alfa
• Applications: Investigated for use/treatment in blood preservative, blood (blood forming organ disorders, unspecified), sepsis and septicemia, and thrombosis.
• Examples of Clinical Use: Sepsis, septicemia, and thrombosis.
• Pharmacodynamics: The product, a recombinant human soluble TM, enhances activation of pro-carboxypeptidase B2 (pro-CPB2) by thrombin. Activated pro-CPB2 (CPB2) exerts anti-inflammatory and anti-fibrinolytic activities.
• Mechanism of action: Thrombomodulin alfa is a soluble form of recombinant human thrombomodulin comprising all extracellular domains of thrombomodulin. Bound to thrombin, Thrombomodulin alfa inhibits its procoagulant activity and promotes activation of protein C. Thrombomodulin alfa inhibits thrombin generation by the activation of protein C and the subsequent inactivation of factor Va in the presence of protein S. Thrombomodulin alfa attenuates the extension of the clot by inhibiting further thrombin generation on clots, while other anticoagulants inhibit the initiation of clot formation. A higher concentration of Thrombomodulin alfa is needed to affect clotting time and platelet aggregation than thrombin generation.
• Affected organisms: Not Available
• Targets: Target 1. Prothrombin; Target 2. Coagulation factor V