PRO 542 (CD4-immunoglobulin G2)

Specification Drug Information Related Products

Cat#:	THP-0188
Product Name:	PRO 542 (CD4-immunoglobulin G2)
Description:	The product (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isolates.
Sequences:	Not Available
Molecular Weight:	Not Available
Purity:	>99% by SDS-Page and HPLC analysis
Cas No:	Not Available
Formula:	Not Available
Endotoxin Level:	<0.001 EU per 1 μg of the peptide by the LAL method

Drug Name:	PRO-542
Applications:	Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications.
Examples of Clinical Use:	Acquired immune deficiency syndrome (AIDS) and aids-related infections, HIV infection, and pediatric indications
Pharmacodynamics:	Not Available
Mechanism of action:	PRO 542 binds to the viral surface glycoprotein gp120 and blocks attachment and entry of virus into CD4(+) cells.Unlike currently approved therapies that block viral replication in cells already infected with HIV, PRO 542 is an antibody-like molecule that is designed to target and neutralize the virus in the bloodstream. Single doses of PRO 542 reduced concentrations of the human immunodeficiency (HIV) in the blood by 60% to 80% in a target population of highly treatment-experienced patients with PRO 542-sensitive virus.
Affected organisms:	Not Available
Targets:	Target 1. Free fatty acid receptor 4