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Platelet-Derived Growth Factor-BB (PDGF-BB)

Cat# : THP-0226

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Catalog# Product Name Availability Size Price Qty
THP-0226 Platelet-Derived Growth Factor-BB (PDGF-BB) May 18, 2024 100ug $798.00
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Cat#:  THP-0226
Product Name:  Platelet-Derived Growth Factor-BB (PDGF-BB)
Description:  PDGF-BB isomer is found to be critical in angiogenesis and is highly expressed in tumor, mediating oncogenic pericyte recruitment. PDGF-BB is an important regulator of bone homeostasis, repair and regeneration. Potency: 1.0-3.0 ng/mL EC50.
Species:  Human
Molecular Weight:  25 kDa
Source:  E. coli
Introduction:  Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes. PDGF significantly activates chemotaxis of neutrophils, monocytes, and fibroblasts. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding. PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair. Platelet-derived growth factor (PDGF) is expressed as homo and heterodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD. The PDGF gene is highly conserved mapped to human chromosome 7p22.3. The active form of Pdgf exists as disulfide-linked dimers. It consists of cystine-knot-fold growth factor domain, which is highly conserved, except for the N-terminal prodomain, which shows variation in length among the isoforms.
Purity:  ≥98% (HPLC and SDS-PAGE)
Formulation:  Lyophilized from a 0.2 μm filtered solution in 30 mM acetic acid.
Biological Activity:  The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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