PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo. Potency: 1.0-3.0 ng/mL ED50.
28.5 kDa (containing 250 amino acid residues)
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors. Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis.
≥98% (SDS-PAGE and HPLC)
Lyophilized from a sterile filtered buffered solution.
The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.
Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.
Examples of Clinical Use:
Vascular endothelial growth factor expression is regulated by PDGF-AA.
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