Cat# : THP-0270
|Product Name:||Interferon Tau (IFN-Tau)|
|Description:||IFN-Tau Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton. The IFN-Tau is purified by proprietary chromatographic techniques.|
|Molecular Weight:||19.9 kDa|
|Introduction:||Interferon tau is a Type I interferon made up of a single chain of amino-acids. In many species of ruminant, it acts as a signaling molecule during pregnancy. It is secreted by the trophoblast cells into the uterine lumen in days 13-21 of pregnancy. It decreases endometrial oxytocin receptors, which then cannot stimulate PGF-2-alpha synthesis, preventing luteolysis. It promotes uterine implantation by increasing protein synthesis in glands. Although its role in humans is not certain, it has been found to bind to the same receptors sensitive to interferon alpha, and thus may have anti-viral properties, as hinted by studies showing its ability to inhibit the reverse transcriptase enzyme found in retroviruses such as HIV. Its low toxicity compared to other interferons also supports its investigation as a potential therapeutic compound.|
|Purity:||>95.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.|
|Formulation:||Sterile Filtered White lyophilized (freeze-dried) powder. Lyophilized from (1mg/ml) solution containing PBS pH-7.4.|
|Biological Activity:||The specific activity as determined in a viral resistance assay using bovine kidney MDBK cells was found to be 10,000,000IU/mg.|
|Reconstitution:||It is recommended to reconstitute the lyophilized IFN Tau in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.|
|Applications:||It decreases endometrial oxytocin receptors, which then cannot stimulate PGF-2-alpha synthesis, preventing luteolysis. It promotes uterine implantation by increasing protein synthesis in glands.|
|Examples of Clinical Use:||Preventing luteolysis and promoting uterine implantation.|
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