Follitropin, Human follicle stimulating hormone (FSH)

Specification

• Cat#: THP-0142
• Product Name: Follitropin, Human follicle stimulating hormone (FSH)
• Description: The product is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. The product beta is produced in genetically engineered CHO.
• Sequences: APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
• Species: Human
• Molecular Weight: 22672.9 Da
• Source: CHO
• Purity: >99% by SDS-Page and HPLC analysis
• Cas No: 146479-72-3
• Formula: C975H1513N267O304S26
• Endotoxin Level: <0.001 EU per 1 μg by the LAL method
• Biological Activity: 450 IU/0.75ml

Pharmaceutical Information

• Pharmaceutical Application: Follitropin
• Applications: In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. In men with hypogonadotrophic hypogonadism, it is used to induce spermatogenesis. The product may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).
• Examples of Clinical Use: Primary ovarian failure and hypogonadotrophic hypogonadism
• Pharmacodynamics: Used for the treatment of female infertility, Follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component is the primary hormone responsible for follicular recruitment and development.
• Mechanism of action: Follitropin is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
• Affected organisms: Humans and other mammals
• Targets: Target 1. Follicle-stimulating hormone receptor