Follitropin, Human follicle stimulating hormone (FSH)

Specification

• Cat#: THP-0142
• Product Name: Follitropin, Human follicle stimulating hormone (FSH)
• Cas No: 146479-72-3
• Description: The product is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. The product beta is produced in genetically engineered CHO.
• Sequences: APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
• Species: Human
• Molecular Weight: 22672.9 Da
• Source: CHO
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C975H1513N267O304S26
• Endotoxin: <0.001 EU per 1 μg by the LAL method
• Biological Activity: 450 IU/0.75ml
• Application: In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. In men with hypogonadotrophic hypogonadism, it is used to induce spermatogenesis. The product may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).

Pharmaceutical Information

• Pharmaceutical Application: Follitropin
• Targets: Target 1. Follicle-stimulating hormone receptor