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Arylsulfatase A (ARSA)

Cat# : THP-0282

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0282 Arylsulfatase A (ARSA) December 02, 2023 50ug $798.00
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Cat#:  THP-0282
Product Name:  Arylsulfatase A (ARSA)
Description:  Recombinant human ARSA (Arg19-Ala507) corresponds to the mature chain and has sulfatase activity described above. This protein is fused 10-His tag at the C-terminal.
Species:  Human
Molecular Weight:  Predicted Molecular Mass: 53 kDa; SDS-PAGE: 63 kDa, reducing conditions.
Source:  Mouse myeloma cell line
Introduction:  As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507).
Purity:  >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Formulation:  Supplied as a 0.2 μm filtered solution in Tris and NaCl.
Biological Activity:  Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS). The specific activity is >25 pmol/min/µg, as measured under the described conditions.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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