Cat# : THP-0282
Catalog# | Product Name | Availability | Size | Price | Qty |
---|---|---|---|---|---|
THP-0282 | Arylsulfatase A (ARSA) | October 08, 2024 | 50ug | $798.00 |
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Cat#: | THP-0282 |
Product Name: | Arylsulfatase A (ARSA) |
Description: | Recombinant human ARSA (Arg19-Ala507) corresponds to the mature chain and has sulfatase activity described above. This protein is fused 10-His tag at the C-terminal. |
Species: | Human |
Molecular Weight: | Predicted Molecular Mass: 53 kDa; SDS-PAGE: 63 kDa, reducing conditions. |
Source: | Mouse myeloma cell line |
Introduction: | As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507). |
Purity: | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Formula: | Supplied as a 0.2 μm filtered solution in Tris and NaCl. |
Biological Activity: | Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS). The specific activity is >25 pmol/min/µg, as measured under the described conditions. |
Application: | The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. |
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