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Andexanet alfa, Recombinant human coagulation Factor Xa

Cat# : THP-0048

Product Datasheets
Catalog#Product NameAvailabilitySizePriceQty
THP-0048 Andexanet alfa, Recombinant human coagulation Factor Xa November 26, 2022 50ug $298
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THP-0048 Andexanet alfa, Recombinant human coagulation Factor Xa November 26, 2022 100ug $498
Add to Cart Online Order Request a Bulk Order
Cat#:  THP-0048
Product Name:  Andexanet alfa, Recombinant human coagulation Factor Xa
Description:  The product is a recombinant human coagulation Factor Xa that promotes blood coagulation. The product works by binding to Factor Xa inhibitors and prevent them from interacting with endogenous Factor Xa. The product retains the structural similarity to that of endogenous human factor Xa, but exists in its mature functional form without the need for activation via the intrinsic or extrinsic coagulation pathways and remains catalytically inactive due to structural modification. The procoagulation potential of the product is eliminated through the removal of a 34-residue fragment containing Gla: via this truncation, it is unable to bind to membrane surfaces and assemble the prothrombinase complex. It also prevents the product from taking up space on phospholipid surface membranes, so that native FXa may bind and assemble the prothrominase complex. The amino acid residue modification from serine to alanine in the binding site of the catalytic domain allows more effective binding to FXa inhibitors and deters it from converting prothrombin to thrombin.
Sequences:  ANSFLFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRRKRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDAGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Species:  Human
Molecular Weight:  Not Available
Purity:  >99% by SDS-Page and HPLC analysis
Cas No:  1262449-58-0
Formula:  Not Available
EndotoxinLevel:  <0.001 EU per 1 μg of the peptide by the LAL method
BiologicalActivity:  100 mg/10mL
Storage:  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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  • Size: 100ug 500ug 1mg 5mg 10mg 100mg 500mg 1g
  • Conjugation: None R-PE APC Biotin FITC Alexa Flour Others
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