Somatrem; Recombinant HGH

Specification

• Cat#: THP-0035
• Product Name: Somatrem; Recombinant HGH
• Cas No: 82030-87-3
• Description: The protein has the same amino acid sequence as human growth hormone except for an extra methionine at the end of the sequence chain to facilitate its manufacturing process. As endogenous growth hormone, it binds to dimeric growth hormone (GH) receptors located within the cell membranes of target tissue cells resulting in intracellular signal transduction and a host of pharmacodynamic effects.
• Sequences: Not Available
• Species: Human
• Molecular Weight: 22255.9518 Da
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C995H1537N263O301S8
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Biological Activity: 3.3IU/mg
• Application: The product is a recombinant human growth hormone indicated for: (a) treatment of paediatric patients with growth failure due to growth hormone deficiency (GHD), (b) treatment of paediatric patients with growth failure due to idiopathic short stature (ISS), (c) treatment of paediatric patients with growth failure due to Turner syndrome (TS), (d) treatment of paediatric patients with growth failure due to chronic kidney disease (CKD) up to the time of renal transplantation, (e) treatment of adults with childhood-onset GHD, or (f) treatment of adults with adult-onset GHD.

Pharmaceutical Information

• Pharmaceutical Application: Somatrem
• Targets: Target 1. Growth hormone receptor; Target 2. Insulin-like growth factor 1 receptor