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Pegloticase, Recombinant procine-like uricase

Cat# : THP-0105

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0105 Pegloticase, Recombinant procine-like uricase March 01, 2024 0.5mg $3,998.00
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Cat#:  THP-0105
Product Name:  Pegloticase, Recombinant procine-like uricase
Description:  The product is a recombinant procine-like uricase. Similarly to rasburicase, pegloticase metabolises the conversion of uric acid to allantoin. This reduces the risk of precipitate formation and development of gout, since allantoin is five to ten times more soluble than uric acid. Pegloticase is a pegylated form of uricase which offers an extended half-life of ten-12 days compared to rasburicase's 8 hours. It also offers reduced immunogenicity due to the bulky PEG group. The longer haf-life allows for less frequent dosing at once every 2-4 weeks making pegloticase more convenient for chronic use.
Sequences:  TYKKNDEVEFVRTGYGKDMIKVLHIQRDGKYHSIKEVATTVQLTLSSKKDYLHGDNSDVIPTDTIKNTVNVLAKFKGIKSIETFAVTICEHFLSSFKHVIRAQVYVEEVPWKRFEKNGVKHVHAFIYTPTGTHFCEVEQIRNGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCKWRYHQGRDVDFEATWDTVRSIVLQKFAGPYDKGEYSPSVQKTLYDIQVLTLGQVPEIEDMEISLPNIHYLNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLSSRL
Molecular Weight:  34192.8533 Da
Purity:  >99% by SDS-Page and HPLC analysis
Cas No:  885051-90-1
Formula:  C1549H2430N408O448S8
Endotoxin Level:  <0.001 EU per 1 μg by the LAL method
Biological Activity:  8 mg/ml
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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