Cat# : THA-0128
Cat#: | THA-0128 |
Product Name: | Nemolizumab |
Description: | Nemolizumab is an interleukin-31 receptor alpha antagonist used to treat prurigo nodularis in adults. |
Sequences: | Nemolizumab heavy chain: QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYIMNWVRQAPGQGLEWMGLINPYNGGTDYNPQFQDRVTITADKSTSTAYMELSSLRSEDTAVYYCARDGYDDGPYTLETWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSP Nemolizumab light chain: DIQMTQSPSSLSASVGDRVTITCQASEDIYSFVAWYQQKPGKAPKLLIYNAQTEAQGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHHYDSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Molecular Weight: | 144000.0 Da (approximate) |
Introduction: | Nemolizumab is a humanized monoclonal modified immunoglobulin 2 (IgG2) antibody directed against interleukin-31 receptor alpha (IL-31RA), which is an endogenous cytokine implicated in the pathophysiology of various skin inflammatory disorders. By binding to IL-31RA, nemolizumab blocks the IL-31 signalling cascades that lead to inflammation. Nemolizumab gained its first global approval in Japan on March 28, 2022, for the treatment of atopic dermatitis. It was later approved by the FDA on August 13, 2024, for the treatment of prurigo nodularis. |
Purity: | >99% by SDS-Page and HPLC analysis |
Formula: | C6384H9814N1678O2034S48 |
Appearance: | Solid |
Endotoxin Level: | < 0.001 EU/μg of the protein by the LAL method |
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