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Margetuximab

Cat# : THA-0123

Product Datasheets COA :
Cat#:  THA-0123
Product Name:  Margetuximab
Description:  Margetuximab is an Fc-engineered human/mouse chimeric IgG1魏 anti-HER2 monoclonal antibody indicated for patients with HER2-positive metastatic breast cancer.
Introduction:  The HER2 oncoprotein, the product of the human ERBB2/mouse neu genes, is a member of the HER family of receptor tyrosine kinases that includes the epidermal growth factor receptor (EGFR). Of the various subtypes of breast cancer, HER2-positive breast cancer is characterized by ERBB2 overexpression, a higher grade, a more aggressive phenotype, and a worse prognosis compared to HER2-negative cancer. The introduction of trastuzumab improved patient outcomes in HER2-positive breast cancer, but notably depended substantially on polymorphisms in the FcγRIIIA/CD16A receptor, whereby low affinity 158F CD16A variants are associated with shorter progression-free survival and worse patient outcomes. Margetuximab (formerly MGAH22) is an Fc-engineered human/mouse chimeric anti-HER2 IgG1κ monoclonal antibody derived from the same mouse 4D5 clone that trastuzumab is derived from and is produced in Chinese Hamster Ovary (CHO) culture. Margetuximab binds to the same epitope on the HER2 extracellular domain and induces the same effects as trastuzumab. However, due to its modified Fc region, margetuximab binds with higher affinity to both CD16A variants and exhibits weaker binding to the inhibitory CD32B Fc receptor, resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and increased efficacy compared to trastuzumab. Margextuximab was granted FDA approval on December 16, 2020, and is currently marketed under the trademark MARGENZA鈩?by MacroGenics, Inc.
Purity:  >99% by SDS-Page and HPLC analysis
Appearance:  Liquid
Endotoxin Level:  < 0.001 EU/μg of the protein by the LAL method
Not For Human Consumption!

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  • Size: 100ug 500ug 1mg 5mg 10mg 100mg 500mg 1g
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