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Idursulfase, Human iduronate-2-sulfatase(IDS)

Cat# : THP-0178

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0178 Idursulfase, Human iduronate-2-sulfatase(IDS) April 20, 2024 100ug $1,498.00
300ug $3,998.00
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Cat#:  THP-0178
Product Name:  Idursulfase, Human iduronate-2-sulfatase(IDS)
Description:  The product is a purified form of human iduronate-2-sulfatase(IDS), a lysosomal enzyme, expressed in a human cell line. The product is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various cell types. The product is a 525-amino acid glycoprotein with a molecular weight of approximately 76 KDa. The enzyme contains eight asparagine-linked glycosylation sites occupied by complex oligosaccharide structures. The enzyme activity of the product is dependent on the post-translational modification of a specific cysteine to formylglycine.
Species:  Human
Molecular Weight:  76000.0 Da
Source:  Human Cells
Purity:  >99% by SDS-Page and HPLC analysis
Cas No:  50936-59-9
Formula:  C2654H4000N688O774S14
Endotoxin Level:  <0.001 EU per 1 μg of the peptide by the LAL method
Biological Activity:  2mg/ml
Publication:  Characterization of a HIR-Fab-IDS, Novel Iduronate 2-Sulfatase Fusion Protein for the Treatment of Neuropathic Mucopolysaccharidosis Type II (Hunter Syndrome) (Gusarova, V.D., Smolov, M.A., Lyagoskin, I.V. et al.) (BioDrugs ) (2023).
iPS-derived neural stem cells for disease modeling and evaluation of therapeutics for mucopolysaccharidosis type II (Hong, J., Cheng, Y., Yang, S.,et al.) (Experimental Cell Research) (2022).
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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