Fibrinogen Human

Specification

• Cat#: THP-0070
• Product Name: Fibrinogen Human
• Description: The product is a hematological agent and a soluble plasma glycoprotein with a molecular weight of about 340 kDa. It is a physiological substrate for three enzymes: plasmin, factor XIIIa and thrombin.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Cas No: 9001-32-5
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg of the protein by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: Fibrinogen Human
• Applications: For the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
• Examples of Clinical Use: Acute bleeding episodes in congenital fibrinogen deficiency
• Pharmacodynamics: Fibrinogen replaces the missing, or low coagulation factor.
• Mechanism of action: Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. The native molecule is a dimer and consists of three pairs of polypeptide chains (Aα, Bβ and γ). Fibrinogen is a physiological substrate of three enzymes: thrombin, factor XIIIa, and plasmin. During the coagulation process, thrombin cleaves the Aα and Bβ chains releasing fibrinopeptides A and B (FPA and FPB, respectively). FPA is separated rapidly and the remaining molecule is a soluble fibrin monomer (fibrin I). The slower removal of FPB results in formation of fibrin II that is capable of polymerization that occurs by aggregation of fibrin monomers. The resulting fibrin is stabilized in the presence of calcium ions and by activated factor XIII, which acts as a transglutaminase. Factor XIIIa-induced cross-linking of fibrin polymers renders the fibrin clot more elastic and more resistant to fibrinolysis. Cross-linked fibrin is the end result of the coagulation cascade, and provides tensile strength to a primary hemostatic platelet plug and structure to the vessel wall.
• Affected organisms: Humans and other mammals