Factor IX Complex (Human)

Specification

• Cat#: THP-0068
• Product Name: Factor IX Complex (Human)
• Description: The product is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Source: Human Plasma
• Cas No: 37224-63-8
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 500U/10ml

Pharmaceutical Information

• Pharmaceutical Application: Factor IX Complex (Human)
• Applications: The product is indicated for the prevention and control of hemorrhagic episodes in hemophilia B patients. It is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding or who require rapid reversal of therapy.
• Examples of Clinical Use: Hemorrhagic episodes in hemophilia B
• Pharmacodynamics: Not Available
• Mechanism of action: Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra(FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin.
• Affected organisms: Not Available