Browse by Product Category
In modern clinical diagnostics, the use of high-quality antigens and reagents is essential for the accurate detection and monitoring of various diseases and health conditions. Diagnostic antigens and reagents serve as the basis for in vitro diagnostic (IVD) assays, enabling the precise identification of biomarkers associated with infectious diseases, chronic diseases, metabolic disorders, organ function, and more.
Creative BioMart's comprehensive portfolio of diagnostic antigens and reagents is designed to meet the needs of diagnostic laboratories, research institutions, and healthcare professionals. We offer a wide range of products covering critical diagnostic areas including allergy, cancer, chronic diseases, infectious diseases, kidney and liver function, metabolic panels, pregnancy and fertility, and synthetic diagnostics. Each category is formulated with precision to ensure high sensitivity and specificity in diagnostic applications.
Background of Diagnostic Antigens and Reagents
Types of Diagnostic Antigens
Accurate disease diagnosis is the cornerstone of effective healthcare, and high-quality diagnostic antigens and reagents are essential for reliable test results. Our diverse product portfolio is designed to support diagnostic manufacturers, research institutions and clinical laboratories in their mission to provide accurate and timely diagnoses.
Diagnostic antigens are primarily categorized based on their source and function:
- Native Antigens: Extracted from pathogens or human tissues, native antigens closely mimic natural biomolecules and provide high specificity in diagnostic assays. Examples include bacterial and viral surface proteins used in infectious disease diagnostics.
- Recombinant Antigens: Genetically engineered recombinant antigens offer high purity, batch-to-batch consistency, and scalability. They are widely used in vaccine development and serologic testing (e.g., recombinant SARS CoV-2 spike proteins for COVID-19 testing).
- Synthetic Peptides: Short, lab-synthesized amino acid sequences, synthetic peptides are highly specific and are used in epitope mapping, autoimmune disease diagnostics, and cancer biomarker discovery.
Types of Diagnostic Reagents
Diagnostic reagents can be classified based on their function in assays:
- Enzyme-Linked Reagents: Enzymes such as horseradish peroxidase (HRP) and alkaline phosphatase (ALP) are used in enzyme-linked immunosorbent assays (ELISA) to generate detectable signals.
- Fluorescent Reagents: Fluorophore-labeled antibodies or dyes are used in fluorescence immunoassays and flow cytometry for highly sensitive biomarker detection.
- Chromogenic Reagents: These reagents produce colorimetric changes in response to antigen-antibody interactions, commonly used in rapid test kits.
- Lateral Flow Reagents: Colloidal gold and latex beads are used in point-of-care lateral flow assays, such as pregnancy tests and COVID-19 antigen tests.
Production and Standardization of Diagnostic Antigens and Reagents
- Recombinant Antigen Production: Production of recombinant antigens involves cloning target genes into expression systems such as Escherichia coli, yeast, mammalian or insect cells. The expressed proteins are purified by affinity chromatography to ensure high purity and functionality. This method enables scalable production of antigens for diagnostic applications.
- Purification and Validation: Antigens and reagents must be purified to remove contaminants that can cause false-positive or false-negative results. Techniques such as column chromatography, ultrafiltration, and centrifugation are used. Rigorous validation by ELISA, Western blotting, and mass spectrometry ensures antigen integrity and specificity.
- Quality Control and Regulatory Compliance: Regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) impose strict quality control measures on diagnostic reagents. Standardization ensures lot-to-lot consistency, sensitivity, and specificity.
Our Product Categories
- Allergy Diagnostics: Allergic reactions are triggered by the immune system's hypersensitivity to specific allergens. Our allergy diagnostic antigens are designed to detect IgE-mediated responses to various allergens, which are essential for in vitro allergy testing and personalized treatment strategies.
- Cancer Diagnostics: Cancer biomarkers play a crucial role in early cancer detection, prognosis, and treatment monitoring. Our diagnostic reagents support a wide range of tumor marker tests, including those for breast, prostate, lung and liver cancers. we offer recombinant and native proteins for key biomarkers such as lactate dehydrogenase (LDH) and prostatic acid phosphatase (PAP).
- Chronic Disease Diagnostics: Chronic diseases such as cardiovascular disease, diabetes and autoimmune disorders require continuous monitoring for effective disease management. Our diagnostic reagents support testing for conditions such as diabetes, hypertension, rheumatoid arthritis, and cardiovascular disease markers.
- Infectious Disease Diagnostics: Timely and accurate identification of infectious diseases is essential for disease control and patient management. We provide high quality antigens and reagents for the detection of bacterial, viral and fungal infections.
- Kidney Function Diagnostics: Renal function assessment is crucial in detecting kidney diseases and monitoring treatment efficacy. Our native uricase and native buttermilk xanthine oxidase, supporting clinical chemistry assays and automated diagnostic platforms.
- Liver Function Diagnostics: Liver health assessment involves the measurement of key enzymes and proteins. Our native bovine liver alkaline phosphatase (ALP) can be used to diagnose liver function.
- Metabolic Panel: Our metabolic panel diagnostic reagents include a comprehensive range of tests to assess metabolic health, including glucose, lipid profiles and protein levels. These reagents are essential for evaluating metabolic disorders, endocrine conditions, and nutritional deficiencies.
- Synthetic Diagnostic Products: In addition to natural antigens, we provide synthetic diagnostic reagents engineered for enhanced stability, reproducibility, and performance in diagnostic applications. Our synthetic antigens are ideal for assay development and quality control in immunodiagnostic platforms.
Advantages of Our Diagnostic Antigens and Reagents
- High Purity and Specificity: Our diagnostic antigens and reagents are developed to deliver precise and reproducible results, ensuring reliable disease detection with minimal cross-reactivity.
- Extensive Product Portfolio: We offer an extensive selection of diagnostic reagents across multiple disease categories, making it easy for diagnostic laboratories and researchers to find the right products for their specific needs.
- Optimized for Various Diagnostic Platforms: Our products are compatible with multiple diagnostic methods, including ELISA, lateral flow assays, chemiluminescent immunoassays (CLIA), and polymerase chain reaction (PCR)-based diagnostics.
- Lot-to-Lot Consistency: We maintain strict quality control protocols to ensure batch-to-batch consistency, providing reliable and reproducible results across different assays.
- Stable and Scalable Manufacturing: State-of-the-art manufacturing facilities and rigorous quality assurance ensure high-yield production of diagnostic reagents with extended shelf-life stability.
Accurate disease diagnosis is the cornerstone of effective healthcare, and high-quality diagnostic antigens and reagents are essential for reliable test results. Our diverse product portfolio is designed to support diagnostic manufacturers, research institutions and clinical laboratories in their mission to provide accurate and timely diagnoses.
Partner with Creative BioMart for cutting-edge diagnostic solutions that improve disease detection and patient care. Contact us today to learn more about our diagnostic antigens and reagents.
