Antithymocyte immunoglobulin (rabbit)

Specification

• Cat#: THA-0021
• Product Name: Antithymocyte immunoglobulin (rabbit)
• Description: Antithymocyte immunoglobulin (rabbit) is a purified form of rabbit anti-thymocyte antibodies used for immunosuppression in patients receiving kidney transplants.
• Sequences: Not Available
• Species: Rabbit
• Molecular Weight: Not Available
• Introduction: Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: Not Available
• Appearance: Liquid
• Endotoxin Level: < 0.001 EU/μg of the protein by the LAL method

Pharmaceutical Information

• Pharmacodynamics: Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.
• Targets: Major histocompatibility complex class I-related gene protein Integrin alpha-L T-lymphocyte activation antigen CD86 Low affinity immunoglobulin gamma Fc region receptor II-b T-cell surface glycoprotein CD4 Integrin beta-1 Integrin alpha-V Integrin beta-3 T-cell surface glycoprotein CD1a