Thyrotropin alfa; Recombinant thyroid stimulating hormone

Specification

• Cat#: THP-0005
• Product Name: Thyrotropin alfa; Recombinant thyroid stimulating hormone
• Cas No: 194100-83-9
• Description: The product is a recombinant form of thyroid stimulating hormone. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of the product is identical to that of human pituitary thyroid stimulating hormone.
• Sequences: Alpha chain APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCC VAKSYNRVTVMGGFKVENHTACHCSTCYYHKS Beta chain FCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYR TVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSY
• Species: Human
• Molecular Weight: 22672.9 Da
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C975H1513N267O304S26
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Application: For detection of residueal or recurrent thyroid cancer.
• Concentration: 0.9 mg/1mL

Pharmaceutical Information

• Pharmaceutical Application: Thyrotropin Alfa
• Targets: Target 1. Thyrotropin receptor