Cat# : THP-0135
|THP-0135||Reteplase, Recombinant Human tissue plasminogen activator||June 05, 2023||1 vial||$3,998.00||
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|Product Name:||Reteplase, Recombinant Human tissue plasminogen activator|
|Description:||Recombinant Human tissue plasminogen activator(tPA), purified, glycosylated, 355 a.a. expressed in CHO cells. The product is genetically engineered to retain and delete certain portions of human tPA. The product is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. The product contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from the product - kringle-1, finger, and epidermal growth factor (EGF).|
|Molecular Weight:||39589.6 Da|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg of the protein by the LAL method|
|Biological Activity:||10.4 unit / vial|
|Applications:||For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction.|
|Examples of Clinical Use:||Acute pulmonary emboli, intracoronary emboli and myocardial infarction|
|Pharmacodynamics:||The product cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.|
|Mechanism of action:||Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.|
|Affected organisms:||Humans and other mammals|
|Targets:||Target 1. Plasminogen; Target 2. Fibrinogen alpha chain; Target 3. Urokinase plasminogen activator surface receptor; Target 4. Plasminogen activator inhibitor 1|
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