Regramostim, GM-CSF

Specification

• Cat#: THP-0186
• Product Name: Regramostim, GM-CSF
• Cas No: 127757-91-9
• Description: Human GM-CSF (Granulocyte/Monocyte-Colony Stimulating Factor) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-α, IL-1, IL-2 and IFN-γ. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.
• Sequences: APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQT ITFESFKENL KDFLLVIPFD CWEPVQE
• Species: Human
• Molecular Weight: 14305.3332
• Source: CHO Cells
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C637H1003N171O187S8
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Application: Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant.

Pharmaceutical Information

• Pharmaceutical Application: Regramostim
• Targets: Target 1. Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; Target 2. GM-CSF receptor alpha subunit