A highly purified and active preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (Human Recombinant) is expressed in CHO cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase (PH20). The purified hyaluronidase glycoprotein contains 447 amino acids with an approximate molecular weight of 61,000 Daltons.
6.5KU/ml to 400KU/ml Unit definition: One unit will cause a change in A600nm of 0.330 per minute at pH 5.7 at 37 oC.
Hyaluronidase (Human Recombinant)
Indicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.
Examples of Clinical Use:
Absorption and dispersion of other injected drugs and resorption of radiopaque agents.
The product hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. The product is used for enhancing absorption and distribution of other injected drugs.
Mechanism of action:
The family of hyaluronidase enzymes hydrolyzes hyaluronic acid (a glucoseaminoglycan) which is a major constituent of the interstitial barrier. Hyaluronidase (Human Recombinant) is a highly purified recombinant human hyluronidase which lowers the viscosity of the interstitial barrier by breaking down hyaluronic acid and is under investigation as a chemoadjuvant to facilitate local interstitial drug delivery as well as increase bioavilability.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products
without prior written approval from Creative BioMart.
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