Recombinant Human Erythropoietin

Specification

• Cat#: THP-0067
• Product Name: Recombinant Human Erythropoietin
• Cas No: 11096-26-7
• Description: The product is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow. It is a 165-amino acid erythropoiesis-stimulating glycoprotein produced in cell culture using recombinant DNA technology. It has a molecular weight of approximately 30,400 daltons and is produced by mammalian cells into which the human growth factor gene has been introduced. The product contains the identical amino acid sequence of isolated natural product and has the same biological activity as the endogenous the product.
• Sequences: APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
• Species: Human
• Molecular Weight: 18396.1 Da
• Source: Mammalian cells
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C815H1317N233O241S5
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 8000IU/0.8ml
• Application: Indicated in adult and paediatric patients for the: treatment of anemia due to Chronic Kidney Disease (CKD) in patients on dialysis and not on dialysis.treatment of anemia due to zidovudine in patients with HIV-infection. treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery.

Pharmaceutical Information

• Pharmaceutical Application: Erythropoietin
• Targets: Target 1. Erythropoietin receptor