Recombinant Human coagulation factor IX/F9

Specification

• Cat#: THP-0057
• Product Name: Recombinant Human coagulation factor IX/F9
• Cas No: 181054-95-5
• Description: Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and functional characteristics similar to those of endogenous factor IX. It is not derived from human blood (unlike human Factor IX complex), and is instead produced by a genetically engineered Chinese hamster ovary (CHO) cell line that secretes recombinant Factor IX into cell medium that is then processed and purified for use as a pharmaceutical agent. Recombinant Factor IX is indicated for the control and prevention of bleeding episodes in adult and pediatric patients with congenital factor IX deficiency (Hemophilia B).
• Sequences: YNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAEAVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
• Species: Human
• Molecular Weight: 46548.2 Da
• Source: CHO Cells
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C2041H3136N558O641S25
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 3000U
• Application: For treatment of hemophilia (Christmas disease).

Pharmaceutical Information

• Pharmaceutical Application: Coagulation Factor IX (Recombinant)
• Targets: Target 1. Coagulation factor X; Target 2. Coagulation factor XI; Target 3. Coagulation factor VII; Target 4. Coagulation factor VIII; Target 5. Prothrombin; Target 6. Prolow-density lipoprotein receptor-related protein 1; Target 7. Vitamin K-dependent gamma-carboxylase