The product is a highly selective growth hormone (GH) receptor antagonist. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), it actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
<0.001 EU per 1 μg of the peptide by the LAL method
The product is a growth hormone receptor antagonist used for the treatment of acromegaly.
Examples of Clinical Use:
The product is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. The product selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.
Mechanism of action:
It selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products
without prior written approval from Creative BioMart.
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