Cat# : THP-0174
|THP-0174||Pegfilgrastim, PEGylated Human granulocyte colony stimulating factor (GCSF)||June 05, 2023||1 vial||$3,998.00||
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|Product Name:||Pegfilgrastim, PEGylated Human granulocyte colony stimulating factor (GCSF)|
|Description:||The product is a PEGylated form of filgrastim(Human GCSF) at the N terminus. Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim. However, pegfilgrastim retains the same biological activity as filgrastim and binds to the same G-CSF receptor to stimulate the proliferation, differentiation, and activation of neutrophils.|
|Molecular Weight:||18802.8 Da|
|Endotoxin Level:||<0.001 EU per 1 μg of the peptide by the LAL method|
|Applications:||The product is indicated for use in patients receiving myelosuppressive chemotherapy for non-myeloid malignancies to reduce the incidence of infection.|
|Examples of Clinical Use:||Non-myeloid malignancies|
|Pharmacodynamics:||Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. The product acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. The product has reduced renal clearance and prolonged persistence in vivo as compared to Filgrastim.|
|Mechanism of action:||Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase.|
|Affected organisms:||Humans and other mammals|
|Targets:||Target 1. Granulocyte colony-stimulating factor receptor; Target 2. Neutrophil elastase|
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